The electrochemical behavior’s character of a potential antiviral drug 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-<i>c</i>][1,2,4]triazinide monohydrate

The results of this study the electrochemical transformation 3-R-4-hydroxy-1,4-dihydro-7-X-1,2,4-triazolo[5,1-c][1,2,4] obtained by voltammetry are presented. It was found that derivatives capable reduction in potential range –0.28 to –0.33 V (relative Ag/AgCl) Britton–Robinson buffer at pH = 2. behavior sodium salt 3-nitro-4-hydroxy-7-methylthio-4H-[1,2,4]triazolo[5,1-c][1,2,4]triazinide monohydrate (compound 1), which silico modeling predicted possible biological activity against various tick-borne encephalitis and Coxsackie B3 viruses. At potentials first stage electroreduction 2, main process is three-electron scheme nitro group compound 1. established 1 an aprotic medium reduced ionic form, most likely form ion pair with Na+ cation, aqueous a protonated particle. Based on this, proposed for probable studied compound.